International Multicenter Study on the Validation of the Diagnostic Criteria of type 1 von Willebrand Disease

An international, collaborative study aimed at

  • Standardize clinical and laboratory assessment in order to minimize the measurement biases
  • Evaluate the discriminant power (sensitivity and specificity) of the diagnostic procedures (either history or laboratory alone or their combination), not only to validate criteria or standards for the positive diagnosis of vWd, but, perhaps equally important, to validate criteria for the exclusion of vWd
  • Produce a descriptive picture of this bleeding disorder in symptomatic families
  • Form the basis for future prospective studies (e.g., genetic diagnosis)
     

Download Study Protocol   (last update: 18 August 1998)

Download Data Collection Forms for Type 1 vWD  (last update: 18 August 1998)

Download Data Collection Forms for Type 3 vWD   (last update: 18 August 1998)